One of the popular herbal remedies used as an alternative medicine for pain, Mitragyna speciosa – Kratom, is the evergreen tropical plant indigenous to Southeast Asia. Along with other components such as flavonoids, polyphenols, terpenoid saponins, and several glycosides, Kratom contains various alkaloids.

An alkaloid is one of the pharmacologically active constituents that contribute to Kratom’s therapeutic effects. The alkaloids in Kratom are important as they are the phytochemicals which form the active psychoactive components that make Kratom useful and popular among masses. They provide Kratom the medicinal properties it is known for such as sedation, relief from pain and cough, anti-malarial effects and relaxation.

In this article, we have got the list and the characteristics of Kratom alkaloids that contribute to its therapeutic benefits.

List Of Kratom Alkaloids And Their Characteristics

Kratom was reported to be the most extensively supplied new psychoactive substance by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in 2008 and 2011. Alkaloid content in Kratom varies according to the geographical location and the time of harvest. It also depends largely upon the type of Kratom strain.

According to research, there are more than 40 different alkaloids found in Kratom up till now, the major one being mitragynine.

1) Mitragynine: Antitussive, Adrenergic, Anti-malarial, Anti-depressive

Mitragynine is a hydrophobic indole alkaloid which marks roughly 66% of the total alkaloid content in Kratom. It has been found that mitragynine has a high affinity for mu-opioid receptors.

Thus, it is involved in responses similar to mu-opioid stimulation like mediating pain and depression. It also correlates to the fact that Kratom is effective in reducing opium addiction by decreasing the withdrawal symptoms. However, there is also a risk of its misuse potential that needs to be researched.

Research has shown mitragynine to induce mRNA and protein expression for some cytochrome (CYP) enzymes but the results are not clinically significant. This leads to the finding that concomitantly administering CYP modulating drugs such as carbamazepine, theophylline, digoxin, and warfarin will lead to a clinically significant drug interaction.

Alkaloid mitragynine is also found to directly inhibit the neurons in the lateral hypothalamus which explains its effect of anorexia and weight loss. The anti-depressive effects Kratom is known for are also reported to come mainly from mitragynine. It also possesses anti-malarial properties.

A 2018 study on humans stated that mitragynine does not weaken memory, motor function, and attention nor does it impair the executive function of regular Kratom users.

2) Paynantheine (PAY) – Stimulant, Smooth Muscle Relaxant, Potassium Channel Blocker

Paynantheine is an indole alkaloid which forms approximately 9% of Kratom alkaloids. It has opioid-like and stimulant effects. After Kratom intake paynantheine is reported to be found in urine.

PAY has been shown to restrain twitch contraction as well as inhibit the muscarine receptors on ileal smooth muscles thus, acting as a smooth muscle relaxer. It is suggested to have cardiotoxic properties due to its blocking effect on potassium current in stem cell-derived cardiomyocytes. Furthermore, a study has also reported paynantheine to be a weak antagonist of the mu-opioid receptor.

3) Speciogynine – Smooth Muscle Relaxant, Weak Mu-opioid Antagonist

Speciogynine is found to be 6.6% to 7% of the total alkaloid contents of Kratom. Speciogynine (SG), a diastereomer of Mitragynine is reported to be the third most abundant alkaloid in Kratom, first and second, being mitragynine and paynanthenine respectively. It is said to be structurally similar to opioids.

It also acts as a Smooth muscle relaxer by inhibiting twitch contraction in a naloxone-insensitive manner and inhibiting muscarine receptors in ileal smooth muscle. Additionally, it is suggested to have weak mu-opioid antagonist effect.

4) 7-Hydroxymitragynine (7-HMG): Anti-tussive, Stimulant, Potent Analgesic, Anti-diarrheal

7-HMG possesses the psychoactive properties found in Kratom. It marks approximately 2% of the total alkaloid content. It reinforces the effects of mitragynine partly by mu- and partly by delta-opioid receptors. It has been reported to have a five-fold greater affinity for mu-opioid receptors than mitragynine.

7-HMG is said to have a higher lipid affinity as compared to morphine making it easier to penetrate the blood-brain barrier. Thus, it has more potent analgesic activity. 7-HMG is also a potent anti-tussive. Although it exhibits an anti-diarrheal effect, it has been found to be less constipating than morphine.

5) Speciociliatine: Weak Opioid Agonist

Speciociliatine forms 0.8 – 1 % of alkaloid content in Kratom. It is the C3 stereoisomer of mitragynine.

Research shows that this alkaloid and its metabolites remain unidentified in human urine so far and there is a potential for them to be used as further markers of Kratom use. It inhibits twitch contraction. It is also found to hamper acetylcholine release from presynaptic nerve through ways other than stimulation of opioid receptors.

6) Mitragynine Oxindole B – More Potent Than Morphine, Less Addictive

It forms less than 1% of total alkaloid content found in Kratom. It is three folds more potent than morphine. It has also been found to cause less tolerance, respiratory depression and inhibition of gastrointestinal motility than equivalent doses of morphine. It also appears to lack addictiveness.

7) Ajmalicine – Cerebro-Circulant, Anti-aggregant, Anti-adrenergic (At Alpha-1), Sedative, Anti-convulsant, Smooth Muscle Relaxant

Ajamalicine is also known as Raubasine or δ-yohimbine. It is structurally similar to alkaloids from yohimbine. It acts as an antagonist of α1-adrenergic and α2-adrenergic receptors with a preferential α2 antagonism. This explains its antihypertensive effect.

The book Alkaloids: Biochemistry, Ecology, and Medical Applications elaborate that peripheral stores of nor-adrenaline are depleted by ajmalicine which results in a reduction of peripheral resistance that leads to lowering blood pressure.

It further reduces the catecholamine and serotonin stores in the brain, heart and other organs. It is also found in Rauwolfia serpentine and Catharanthus roseus.

8) Akuammigine: Stimulant, Analgesic, Anti-malarial

It forms less than 1% of the total alkaloid content of Kratom. It is an indole alkaloid and has opioid receptor agonistic effects. Thus, it has stimulatory and analgesic effects. It is also found in Picralima nitida (Akaumma) seeds. It is structurally related to mitragynine and yohimbine and has similar anti-malarial activity.

9) Ciliaphylline: Anti-tussive, Analgesic, Mild Sedative and Anti-diarrheal

It is an oxindole alkaloid. It forms less than 1% of total Kratom alkaloid content. It is present in the stem, trunk and root bark of the plant. It has analgesic and anti-tussive effects. It also has mild sedative and anti-diarrheal effects.

10) Corynantheidine: Anti-hypertensive, α1 and α-2 Adrenergic (α1 Preferentially)

Corynantheidine is also called as rauhimbine. It acts as a functional μ-opioid antagonist and is also found in Yohimbine. It is a diastereomer of yohimbine. It forms less than 1% of the total alkaloid content of Kratom.

It has α1-adrenergic and α2-adrenergic receptor antagonistic effects similar to ajmalicine but has a 10 times preferential affinity for α1 receptors.

11) Corynoxeine: Calcium Channel Blocker, Anti-locomotive, Anti-Parkinson’s Effect

Corynoxeine forms less than 1% of total alkaloid content found in Kratom. It acts as a Calcium channel blocker.

Corynoxine A – It is a dopamine mediator responsible for elevating mood and decreasing anxiety. It acts as an anti-locomotive.

Corynoxine B – An oxindole alkaloid. It acts as a dopamine mediator that enhances the effects of Corynoxine A. A study suggests that it can be used for prevention or treatment of Parkinson’s disease.

12) Epicatechin: Antioxidant, Anti-bacterial, Anti-diabetic, Anti-inflammatory

Epicatechin is a flavonoid which is a biologically active phenol that acts as an antioxidant providing various therapeutic benefits. A 2016 study has shown that epicatechin acts as an effective anti-bacterial agent.

According to the study, it acts against bacteria H. Pylori and provides protection against its infection. It has also been found that epicatechin improves insulin sensitivity and plays a role in alleviating insulin resistance associated with obesity, thereby acting as a natural remedy for diabetes.

It is further found to be an effective Anti-hepatitic agent. It works against the hepatitis C virus (HCV) and its relative diseases by inhibiting HCV replication. Epicatechin has also been established to have effective anti-inflammatory and anti-leukemic properties.

One study shows that it helps in reducing myostatin. This results in muscle growth and improved strength. It’s also found in green tea, dark chocolate, and grapes.

13) 9-Hydroxycorynantheidine: Partial Opioid Agonist

9-Hydroxycorynantheidine is chemically derived from mitragynine, but the reaction not as effective as mitragynine due to its effects were blocked by naloxone in a study conducted on guinea-pig ileum. From the study, it was concluded that 9-Hydroxycorynantheidine has partial agonist properties on opioid receptors in the brain.

14) Isomitraphylline: Immune-stimulant, Anti-leukemic

Isomitraphylline forms less than 1% of the alkaloid content of the Kratom plant. It is found in the stem, trunk bark, and root bark. One of Its effects is that it plays a role in immune system stimulation. Furthermore, it has some anti-leukemic properties.

15) Isomitrafoline: Auxiliary Immune-stimulant

Isomitrafoline makes up less than 1% of the alkaloid content in Kratom. Its structure is related to Isomitraphylline thus, acting as its auxiliary to stimulate the immune system.

16) Isopteropodine: Immune-stimulant, Anti-bacterial

Isopteropodine is one of the alkaloids which stimulate the immune system actively. It demonstrates a potential antibacterial activity by acting against Gram-positive bacteria. Its total alkaloid content is less than 1%.

17) Isospeciofoline: Analgesic, Anti-tussive

Isospeciofoline is a ‘C-9 hydroxy’ isomer of speciofoline. Its total alkaloid content in kratom is less than 1%. Its effects are considered to be similar to speciofoline having analgesic and anti-tussive properties however, more research is needed.

18) Mitraciliatine

Mitraciliatine is one of the indole alkaloids. It is found in leaves, stem, trunk and root barks of Kratom. Its total alkaloid content in Kratom is less than 1%. Studies have confirmed its presence in the urine of Kratom users.

19) Mitrafoline: Anti-hypertensive, Anti-amnesic, Anti-leukemic

Mitrafoline is an oxindole alkaloid. Its total alkaloid content in kratom is less than 1%. It is considered to cause vasodilation. Also, it exerts antihypertensive and anti-amnesic effects. It is said to have muscle-relaxing properties and is a potent anti-leukemic.

20) Mitraphylline

Mitraphylline is also an oxindole alkaloid involved in immune system stimulation. It is structurally comparable to ajmalicine. It acts as a Vasodilator and a muscle relaxant also has diuretic, anti-hypertensive, and anti-amnesic properties and plays a role in potential anti-leukemic characteristics Kratom possesses.

Also, it has shown to have immune-stimulating effects. Its total alkaloid content in kratom is less than 1%.

21) Mitraversine

Found in Mitragyna parvifolia and may also be present in Mitragyna speciosa. It was first isolated by Field et. al in 1921. Very little is known about the alkaloid and needs further research.

22) Rhynchophylline

Rhynchophylline is found in the stem, trunk and root barks of Kratom. It acts as a vasodilator and antihypertensive. It is a potent calcium channel blocker, also acts as anti-aggregant. It can also be used as an antipyretic to reduce fever and has anti-inflammatory activity.

It is further known to make Kratom effective as an anti-arrhythmic and provides an effective treatment of parasitic worms. It is a non-competitive NMDA antagonist and demonstrates its effects on dopamine and 5-HT receptors.

Also found in Chinese Cat’s claw (Uncaria tomentosa). Its chemical structure is correlated with mitragynine.

23) Isorhynchophylline

It is an isomer of rhyncophylline. It is found in leaves, stem, trunk bark and root bark of the kratom plant. It is an oxindole alkaloid, also found in Uncaria species. It is chemically associated with alkaloid mitragynine. It has anti-malarial properties.

It also acts against cardiovascular and central nervous system diseases such as hypertension, bradycardia, sedation, arrhythmia, amnesia and vascular dementia. It has potential anti-coagulant effects. It plays a role in blocking the calcium channels, having effects similar to verapamil. It acts as an immune-stimulant. Its total alkaloid content in kratom is less than 1%.

24) Speciofoline

Speciofoline is an oxindole alkaloid. It plays a role as a mild opioid receptor agonist. It is a potent orally effective analgesic and anti-tussive agent as demonstrated by animal experimentation.

25) Speciophylline

Speciophylline is an indole alkaloid also found in Chinese Cat’s claw (Uncaria tomentosa). It acts against blood cancer due to its anti-leukemic properties. Its total alkaloid content in kratom is less than 1%.

26) Stipulatine

It is an oxindole alkaloid that acts as a mild to moderate opioid receptor agonist. It also has sedative and antioxidant effects. Its total alkaloid content in kratom is less than 1%.

27) Tetrahydroalstonine

It acts as a Hypoglycemic i.e. lowers blood sugar level. It bears anti-adrenergic properties (at alpha-2) receptors. Its total alkaloid content in kratom is less than 1%.

The pain-relieving and relaxing effects of Kratom are sworn by its users. However, the Food and Drug Association U.S. has concerns regarding its safety and addiction.

Also, it has issued a warning against its risks in April 2019. Experts are concerned mainly about the two major Kratom alkaloids namely, mitragynine and 7-a-hydroxymitragynine. These alkaloids are present in high amounts in the Kratom plant and have the most potent effects on the brain.

According to Austin De La Cruz, Pharm.D., clinical assistant professor at Houston University, these alkaloids are most apprehensive because they work by binding to opioids receptors in the brain, particularly mu-opioid receptors that are involved in pain relief and potential euphoric effects. FDA supports more research to be conducted for a better understanding of Kratom and its safety including its effects in combination with other drugs.

A racer at the tracks always has eyes on the finish line. He/she needs to stay focused and must have the energy to reach his goal without falling behind for a second swiftly! For this focus and zeal, numerous athletes train and work on their diet. Dietary supplements also play an integral part in their building as an athlete.

Recently, there was an increase in athletes who use Kratom. Any athlete’s goal is to improve stamina, focus, and build muscles. Athletes often rely on protein supplements, energy boosters, and regular training, and now Kratom is also an essential item on the list.

As with all-natural supplements, athletes must first consult a good doctor and then take this natural substance to boost energy and improve concentration, focus, and determination.

The History Of Kratom and How It Works

Kratom is a mysterious natural supplement that is still juggling between the ‘safe’ and ‘dangerous’ debate. This substance has been in use for centuries in Southeast Asia as traditional medicine. It’s opiate-like, and stimulating qualities make it a good pain killer, and users claim it is advantageous. Why has Kratom become so popular for athletes? Why is there an increase in Kratom use? The answers to these questions are related to the chemical composition of Kratom.

Kratom grows in humid and tropical weather. This botanical substance has become popular due to alkaloids like mitragynine and 7-hydroxymitragynine. These alkaloids activate the brain and energize the body. Users feel excited, stimulated, and happy after using Kratom.

Kratom is not a slow-acting substance, which means that you don’t have to use it for months to see the results. If you consume Kratom, you will feel the effects within a few hours.

There are various types of Kratom based on the color of the leaf vein and the area of origin. The Kratom tree grows in a humid climate, and the different types of this plant have their distinct qualities. Each strain has a specific impact on the user. Users need to study the effects of different kinds of Kratom so that they can pick the one that is right for them.

Kratom and Athletic Performance

There is not sufficient scientific study or research to support the benefits of Kratom for athletes. However, there is ample proof that Kratom helps energize and improve focus. We also know that at lower doses, the natural substance has different effects than those after consuming a more significant amount. Athletes and sportspeople have started using Kratom to build focus and improve physical performance.

A small dose of Kratom can help stimulate, while the same substance in more substantial quantities causes sedation and drowsiness. In the United States, several athletes are related to weight lifting, running, rugby, and sports that involve injuries and pain. Kratom proves beneficial in such situations when an athlete suffers from anxiety and requires immediate relief.

Kratom’s stimulation and focus on increasing properties make it an ideal supplement for athletes. Any athlete needs focus, stamina, motivation, and must remain stress-free to achieve fitness and sports goals. Kratom may not have substantial research to back it, but there is ample proof of efficacy through user reviews!

Sportspeople require performance enhancers that do not impact their health negatively, and Kratom is one of them! Of course, before using Kratom, the type of Kratom and its impact has to be considered.

Different Reasons For Athletes To Take Kratom

Every athlete’s goal is to achieve fitness, performance, stamina, and focus. These goals are the ingredients of success in the field. Kratom delivers all of them through a small dose every day!

The various types of Kratom have a different impact on the body. Similarly, the amount of Kratom you take will also determine the results. Some Kratom varieties stimulate, enhance mood and energize; while other kinds of Kratom can sedate and cause euphoria to take over.

An athlete must know which Kratom variety will suit their goals and take the recommended dosage accordingly. So summarizing this will mean that Kratom can help athletes with:

• Stamina and focus
• Anxiety
• Positivity
• Pain and muscular soreness
• As an analgesic

The Doping Test and Other Complications?

In 2015, during a popular international sports event, the first case of Kratom consumption was reported. A doping control test, done for testing drug use in male athletes, showed the presence of mitragynine and other alkaloids in four specimens. The urine tests of athletes also showed the presence of various metabolites.

Scientists from the German Sports University Cologne said that the use of Kratom for recreational purposes compelled the anti-doping regulatory bodies to monitor the alkaloids in Kratom. They discovered that Kratom might have beneficial properties such as performance enhancement and analgesic effect. In the United States, such researches are on a lower scale.

However, it is legal and allowed to use Kratom. This legality status makes it safe for athletes to use this natural substance and get closer to their goals on the field!

Kratom Is Good For Fighters

MMA fighters, boxers, and wrestlers get the worst of beatings and injuries in the ring. They probably need pain killers with every meal after a rough game! Muscular soreness and injuries are also a constant in the world of fighting sports.

Instead of the same old pain killers, fighters can try Kratom as it is a revolutionizing supplement for fighters for pain as well as strength. Sometimes, a sedating strain may be needed to enjoy a restful and tranquilizing sleep after the tough work.

The USADA, United States Anti-Doping Association, does not recommend the natural substance due to its dangerous side effects. However, for several types of sports, the botanical material may prove to be the most helpful. Fighting is one of them for sure!

Athletes and Celebrities Use Natural Substances Like CBD and Kratom

The MMA fighter Jessamyn Duke tweeted about her association with Online Kratom, an online Kratom store. She posted this status in 2016, and since then Kratom has become more popular. There are numerous athletes and celebrities who use kratom for wellbeing.

Dorian Yates, a former weightlifter also tried this. Bodybuilder Anthony Roberts also spoke about Kratom and how it could help athletes. He opined that Kratom has no opioid-ic qualities when taken in moderation.

Anthony Roberts believes that the natural substance helped laborers and farmers work longer in the fields. This productivity made it popular in Southeast Asian countries for centuries. The natural substance is readily available in the United States now, which makes it easily accessible for athletes.

Like CBD oil, Kratom has a lot of fans in the sports field. Many of the people who used or endorsed natural substances such as CBD are Mike Tyson, Seth Rogen, and Anthony and Sergio Pettis. For Kratom, there are very few users but the increasing amount of research will hopefully change this!

Natural Supplements For The Gym

There are numerous products for athletes and sports persons that include natural substances. CBD by xwerks, Kratom, Acai berry extracts, and several other natural ingredients are believed to help with performance and injuries. CBD oils, hemp creams, and Kratom tea are some of the supplements that gym-goers and athletes use to feel focused and active.

These products can reduce pain while enhancing productivity. Other than creams and balms, CBD is available in daily health threats such as protein bars and smoothies. Kratom is also available in smoothies, shakes, and edibles. Users claim that these sports supplements enhance strength and promote fitness.

The Various Varieties Of Kratom For Sports

As we discussed, the different kinds of Kratom have varying impact on users.

Some strains stimulate while others sedate.

The ideal Kratom pick for sportspeople should be exciting and stress buster so that they can focus during the game without worry!

Thai Kratom comes from mainland Thailand and is used for increasing energy. This strain has a high content of alkaloids, which boost energy and make the user feel active. You will feel upbeat and ready for any challenge after consuming Thai Kratom!

The most dominant Thai strains for energy are Green Vein Thai and White Vein Thai Kratom.

Red vein Thai is also a good supplement for energy, but it is more often associated with pain relief.

Another strain that is used for stimulation and focus is the Maeng Da Kratom. The physical appearance of this Kratom powder is a darker color, and the stem of this Kratom plant is rich in biochemical that enhance the mood and make users feel motivated. When you require results in a short period, Maeng Da Kratom is the right supplement for you!

Vietnam Kratom is another type of plant that is popular for its stimulating and energizing effect. This strain is very similar to the Maeng Da Kratom type, but the results are slightly different as it is more of an energizing strain than a painkilling strain.

Users often feel that this strain improves the clarity of mind for a more extended period. The long-lasting impact helps users to enjoy the stress-free mental focus they want!

Users report that all the White Vein Strains provide more energy and stimulation. The impact of these strains are long-lasting and help athletes and people who have a stressful routine and require concentration.

Dedication to sports and the will to achieve goals is what these Kratom types add to every user’s day!

White Bali is an example of the white vein Kratom category. It increases mind power and physical strength. Sports requires both mental and physical fitness, and this Kratom will enhance an athlete’s game power within minutes of consumption!

This energetic supplement will also improve the cognitive skills of the consumer, enabling him or her to make the right decisions in split seconds.

White Sumatra, White Borneo, and Malay Kratom are other energy-boosting strains that promote energy and uplifts moods to a great extent.

The Green Leaf Variety is a mix of all the attributes that any sportsperson requires to excel. They provide a combination of energy and stimulation with a calming effect on the mind.

These strains help enhance the ability to face challenges with a refreshing approach, enabling users to complete the given task by increasing productivity.

Green vein strains also have a prominent analgesic quality that helps with muscle soreness and pain.

Kratom Tea: A Soothing Yet Stimulating Cup!

Tea is a good way to consume Kratom before a game. The procedure of making it is simple, as it only requires boiled water and some Kratom powder brewed in it for a couple of minutes. The tea is a quick-acting way to take in the Kratom and feel soothed while it stimulates the senses and prepares users for a workout or training routines.

A scientist from the University of Science Malaysia revealed that footballers in Malaysia drink Kratom tea before a match. The scientist researched the efficacy of Kratom for athletes and predicted that athletes in the United States will use the supplement readily in the near future.

The Famous Brands Of Kratom For Sports

While users can buy Kratom from various online vendors, some specific brands sell Kratom for athletes. These products are designed to help athletes achieve physical and mental focus while enjoying the supplement.

Several Kratom products are blends of various strains that promote energy and stimulate the nervous system. These blends are to provide maximum benefits of the strains used.

Some of the prominent brands can be found online, which include Spring Kratom, MHD Kratom, and Ningindo herbals.

You can find several Kratom vendors for your Kratom supply, but the quality is a must!

The freshness and purity of Kratom ensure efficacy. The alkaloids in Kratom are the leading players, and in case your Kratom powder is stale or contaminated, the alkaloids will not be as active. You must ensure that you purchase Kratom from a reliable online store.

These stores provide lab test results and a transparent purchasing experience, so you know what you will receive.

What Users Say About Kratom For Sports?

You can find several user reviews on the various social media platforms. If you are a sportsperson and need to know what users have to say, you can check reviews on Facebook pages and Reddit.

Different athletes and sports-related persons share their experiences.

According to some of the reviews, Kratom helps people increase stamina. For daily workouts and training routines, a dose of Kratom may prove beneficial as it will help achieve fitness goals as well as increase focus. Whether it is running, hockey, tennis, or fighting, Kratom can enhance your abilities to excel and make you a champion!

Kratom has been a major breakthrough in the world of, herbal supplements. Numerous benefits of Kratom have been discovered in the recent years and there’s no end to the health benefits of Kratom.

To all those people who were hopeless out there due to their medical conditions found a miracle drug that helped them get back to their normal life.

No doubt, kratom is a miracle herb. This article lists the top 15 health benefits of Kratom.

If you are experiencing medical conditions like pain, diarrhea, Opiate withdrawal, insomnia, and fatigue, you are at the right place, because Kratom is the magical cure.

What is Kratom?

Kratom is a plant belonging from the Mitragyna Speciosa family, native to the countries of Southeast Asia.

The leaves of this plant the alkaloids that are responsible for producing effects that benefit the health of a person.

Kratom leaves come in three types which include red, green and white. Each of these leaves produces different strains that have different effects.

The stem of Kratom is also used for medicinal benefits. Though Kratom contains more than 40 alkaloids, the major alkaloids are only two in number.

These are 7-hydroxymitragynine and Mitragynine. The effects produced by these alkaloids are mentioned below.

On our list of top 15 health benefits of Kratom, these are some of the effects that Kratom produces.

• Kratom for stimulation

  The stimulant action of Kratom is observed at low doses. This action allows people to work tirelessly and with minimum effort. Stimulation helps in getting energetic and in feeling the positive vibes around you.

  This also has a positive effect on the mental health of a person. Those persons who feel lethargy and are quickly fatigued they need the right dose of energy and motivation to work which is provided by Kratom.

  Unlike other CNS stimulants, it doesn’t give anxiety and jittery feeling.

  

• Kratom produces strong analgesia

  The alkaloids present in Kratom are responsible for the painkilling effect. These alkaloids act on the opiate receptors present in the central nervous system.

  These receptors in return respond to the alkaloids present in Kratom and via signal transduction, they send a message to the neurons and it acts by enhancing the release of enkephalins and endorphins.

  Enkephalins, Dynorphins, and Endorphins are part of the analgesic pathways. These neurotransmitters act by suppressing pain signals that go from the periphery to the brain.

  The Kratom strains that produce strong analgesia include Red Maeng Da, White Maeng Da, and Red Bali.

  A low dose of 2 grams is effective in producing analgesic effects. The analgesia lasts for four to six hours, relieving pain in conditions like osteoarthritis, osteomalacia, osteoporosis, chronic backache, rheumatoid arthritis, joint pain etc.

• Kratom elevate your mood

  All strains of Kratom act in a way to make you feel confident and optimistic but some strains are more euphoric than the others and thus they elevate your mood.

  Borneo and Bali strains of Kratom at small doses ranging from 2 to 6 grams can induce a positive or a happy mood. Maeng Da, Thai and Malay strains are also well known for producing positive mood in a dose ranging from 1 to 4 grams.

  For mild depression, a dosage between 0.5 grams to 2 grams has proven to be effective.

  For moderate depression, 1 to 5 grams of Kratom can be taken. Green and white Kratom strains are productive in the regard that they help stressed persons a lot. Some mood-boosting strains are mentioned below;

  Bali and Borneo Strains
  Maeng Da
  Malay and Indo strains

  

• Kratom for opiate withdrawal

  Kratom is not an opiate but it does have an action that resembles the action of Opiates. It is an agonist at supraspinal mu and delta Opiate receptors.

  It interacts with the Opiate receptors but it doesn’t produce long-term dependency. It helps in returning the appetite to normal.

  It helps in reduction of sleeplessness and pain associated with Opiate withdrawal. Also, it elevates mood and has an anti-anxiety action.

  It reduces cramps, vomiting, and nausea associated with Opiate withdrawal. It reduces the cravings of a person for Opiate when it attaches to the Opiate receptors in the brain.

  Some of the Kratom strains that are important in reducing Opiate withdrawal symptoms include;

  Bali red vein
  Sumatra Red Vein Powder
  Maeng Da
  Green Thai Powder
  Green Malay

  

• Kratom for treating anxiety

  Anxiety is a term that is used for some disorders which include Panic disorder, social anxiety disorder, and specific phobias as well as generalized anxiety disorder.

  The symptoms of anxiety include a feeling of panic, impaired sleeping, fear, uneasiness sweaty and cold hands, palpitations hypoventilation, dryness of mouth, tense muscles with cramps, nausea and sometimes vomiting, paresthesia of extremities, etc.

  Kratom gives you a sense of well-being, and it soothes your nerves.

  You feel relaxed and calm after taking Kratom and thus you start feeling the Anxiolytic action of Kratom. You will feel a noticeable reduction in nervousness.

• Kratom for cognition enhancement

  Cognitive performance is a phenomenon that means the ability to bring the knowledge acquired by various mental processes in use.

  The brain gets its energy from the nutrients and the diet we take.

  Energy is generated after there is metabolism of the diet. Kratom is metabolized by the phase I and phase II microsomal enzymes which are present in the liver, into different alkaloids like mitragynine and 7-hydroxymitragynine.

  These alkaloids act on the mu, delta, and kappa Opiate receptors present in the brain and the periphery.

  Mitragynine is responsible for acting mainly on the delta receptors while 7-hydroxymitragynine acts on the mu receptors.

  These opioids receptors in return are responsible for affecting the cognitive performance. Kratom is known to enhance the cognition of a person.

  

• Kratom for improvement in focus

  Kratom has some important alkaloids that help you in focusing on your work or your studies.

  It does so by releasing larger quantities of acetylcholine that help you stay focused and prevent you from thinking diffusely.

  Along with this Kratom evokes the release of dopamine and serotonin both of which are really important in increasing focus, attention span and keeping you motivated to do a particular task.

  

• Kratom relieves stress

  Being a psychostimulant, Kratom is known to relieve stress. It does so by the release of certain neurotransmitters that enhances the overall mood of a person.

  These neurotransmitters are endorphins and serotonin. This way it can be rightly said that Kratom is a helpful aid and dietary component for people suffering from depression and other stress disorders.

  

• Kratom improves sleeping pattern

  At higher doses, Kratom acts as a sedative and thus helps a person in sleep.

  Those persons who suffer from insomnia, night terrors or parasomnia can take Kratom to relieve it.

  People who take a longer time to sleep, or wake up at the slightest disturbance can also take Kratom to have better sleep.

  If a person has good sleep, he can function better during the daytime. The sedative action of Kratom occurs because it alters the sleep-wake cycle and regulates it.

• Anticonvulsant effect of Kratom

  The anticonvulsant use of Kratom is gaining importance in patients with epilepsy who suffer from seizures.

  This effect is brought about by the action of Kratom in certain areas of the brain that regulate the coordination and movement of the body as well as the sympathetic tone of the muscles.

  By regulating the nerve impulse discharge, Kratom helps in reducing convulsions.

  

• Anti-diarrheal action of Kratom

  Kratom regulates the parasympathetic system which mainly affects the gastrointestinal tract.

  The higher firing rate of a nerve impulse from the parasympathetic ganglia present in the gastrointestinal tract can result in the increased motility of the large intestine thereby leading to diarrhea.

  Kratom reduces the motility of the intestines and helps in making solid stools.

  

• Anti-inflammatory action of Kratom

  Kratom has an anti-inflammatory action, therefore; it is used in rheumatoid arthritis, osteoporosis, and osteoarthritis.

  Kratom promotes healing and reduces pain, swelling, and redness at the site of inflammation.

  

• Anti-oxidant action of Kratom

  The anti-oxidant action of Kratom can be compared to superoxide dismutase and glutathione which are the natural anti-oxidants present in the body.

  Kratom prevents the formation of free radicals and thus protects the body tissues from injury.

  

• Kratom for weight loss

  Kratom regulates satiety center in the hypothalamus of the human brain. People who are obese can take Kratom to reduce their appetite and lose weight by using a natural herb.

  

• Kratom enhances motivation levels

  The active ingredients or alkaloids of Kratom are 7-hydroxy mitragynine and mitragynine.

  These alkaloids show agonism at the opioid receptors present in the brain. Also, they increase the sympathetic activity which results in the release of adrenaline and noradrenaline, also called the ‘adrenaline rush’.

  This is responsible for the boosting motivation. Kratom also induces the release of dopamine and serotonin that are important in enhancing motivation levels. The Kratom strains that produce high motivation include;

  Maeng Da: 1-3 grams dose
  Green Malay: 1-3 grams dose
  Red Borneo: 2-2.5 grams dose
  Red Vein Sumatra: 1-2 grams dose
  White Vein Thai: 2-3 grams dose

  Mentioned above are the top 15 health benefits of Kratom but the list doesn’t end here.

  Kratom has numerous health benefits and it is the time that clinical studies start proving the health benefits of Kratom.